Clinical trials are research studies with volunteer patients to help identify safe and effective treatments. This research empowers people living with the disease help to find the treatments, prevention, and ultimately, the cure for Alzheimer’s and other neurodegenerative diseases.  Dr. Crane believes in providing access to the trials, and the hope it offers patients, their families, and future generations.  

Current Clinical Trials

Alzheimer’s Network for Treatment and Diagnostics (ALZ-NET) 

Sponsored by: Alzheimer’s Association

Managed by: American College of Radiology

Principle Investigator: Dr. Monica Crane, Tennessee Memory Disorders Foundation and Clinic

Trial Documentation: Study Details

“A Phase 3 Double-blind, Randomized, Placebo-controlled, Multi-center, Trial to Evaluate the Efficacy and Safety of AR1001 over 52 Weeks in Participants with Early Alzheimer’s Disease” (POLARIS-AD)

Protocol Number: AR1001-ADP3-US01

Principle Investigator: Dr. Monica Crane, Tennessee Memory Disorders Foundation and Clinic

Trial Documentation: Study Details

UT Collaboration and Innovation on Detection, Care, and Treatment of Alzheimer’s Disease and Related Dementia, University of Tennessee 

Principle Investigator: Dr. Xiaopeng Zhao, University of Tennessee and Dr. Monica Crane, Tennessee Memory Disorders Foundation and Clinic

Trial Documentation: 

A randomised double-blind placebo-controlled clinical trial investigating the effect and safety of oral semaglutide in subjects with early Alzheimer´s disease (EVOKE plus)

Universal Trial Number: U1111-1259-2920

EudraCT Number: 2020-004864-25

IND Number: 146391

Principle Investigator:

Trial Documentation: